node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSF2 | CSF2RB | ENSCPOP00000015585 | ENSCPOP00000018250 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Fibronectin type-III domain-containing protein. | 0.997 |
CSF2 | CSF3R | ENSCPOP00000015585 | ENSCPOP00000009773 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Colony stimulating factor 3 receptor. | 0.914 |
CSF2 | IFNG | ENSCPOP00000015585 | ENSCPOP00000009919 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.843 |
CSF2 | IL1A | ENSCPOP00000015585 | ENSCPOP00000016908 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | 0.872 |
CSF2 | IL1B | ENSCPOP00000015585 | ENSCPOP00000001784 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.863 |
CSF2 | IL2RA | ENSCPOP00000015585 | ENSCPOP00000005118 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin 2 receptor subunit alpha. | 0.854 |
CSF2 | IL5 | ENSCPOP00000015585 | ENSCPOP00000004355 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. | 0.863 |
CSF2 | Il4 | ENSCPOP00000015585 | ENSCPOP00000031420 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-4. | 0.841 |
CSF2 | Il5ra | ENSCPOP00000015585 | ENSCPOP00000007062 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-5 receptor alpha. | 0.912 |
CSF2 | TNF | ENSCPOP00000015585 | ENSCPOP00000002129 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.848 |
CSF2RB | CSF2 | ENSCPOP00000018250 | ENSCPOP00000015585 | Fibronectin type-III domain-containing protein. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.997 |
CSF2RB | IFNG | ENSCPOP00000018250 | ENSCPOP00000009919 | Fibronectin type-III domain-containing protein. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.792 |
CSF2RB | IL2RA | ENSCPOP00000018250 | ENSCPOP00000005118 | Fibronectin type-III domain-containing protein. | Interleukin 2 receptor subunit alpha. | 0.666 |
CSF2RB | IL5 | ENSCPOP00000018250 | ENSCPOP00000004355 | Fibronectin type-III domain-containing protein. | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. | 0.936 |
CSF2RB | Il4 | ENSCPOP00000018250 | ENSCPOP00000031420 | Fibronectin type-III domain-containing protein. | Interleukin-4. | 0.812 |
CSF2RB | Il5ra | ENSCPOP00000018250 | ENSCPOP00000007062 | Fibronectin type-III domain-containing protein. | Interleukin-5 receptor alpha. | 0.933 |
CSF3R | CSF2 | ENSCPOP00000009773 | ENSCPOP00000015585 | Colony stimulating factor 3 receptor. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.914 |
CSF3R | IFNG | ENSCPOP00000009773 | ENSCPOP00000009919 | Colony stimulating factor 3 receptor. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.815 |
CSF3R | IL2RA | ENSCPOP00000009773 | ENSCPOP00000005118 | Colony stimulating factor 3 receptor. | Interleukin 2 receptor subunit alpha. | 0.784 |
CSF3R | IL5 | ENSCPOP00000009773 | ENSCPOP00000004355 | Colony stimulating factor 3 receptor. | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. | 0.784 |