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OPRL1 protein (Cavia porcellus) - STRING interaction network
"OPRL1" - Nociceptin receptor in Cavia porcellus
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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OPRL1Nociceptin receptor; G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception [...] (370 aa)    
Predicted Functional Partners:
PNOC
Prepronociceptin (176 aa)
     
  0.950
Pdyn
Proenkephalin-B; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) (245 aa)
     
  0.915
POMC
Pro-opiomelanocortin; Melanocyte-stimulating hormone alpha- Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes (244 aa)
     
  0.837
CNR1
Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid- induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
     
 
  0.825
PENK
Proenkephalin-A; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum (268 aa)
     
  0.767
SACM1L
SAC1 suppressor of actin mutations 1-like (yeast) (591 aa)
           
  0.758
Oprk1
Kappa-type opioid receptor; G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by r [...] (380 aa)
     
 
0.738
DRD4
Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family (174 aa)
         
  0.717
TRIM13
Tripartite motif containing 13 (407 aa)
           
  0.697
CNR2
Cannabinoid receptor 2 (macrophage); Belongs to the G-protein coupled receptor 1 family (364 aa)
         
  0.693
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, Cavia cobya, Cavia porcellus, domestic guinea pig, guinea pig
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