STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ApfAlpha-1-antiproteinase F; Inhibits elastase, chymotrypsin, cathepsin G, plasmin, and trypsin; Belongs to the serpin family. (405 aa)    
Predicted Functional Partners:
PROC
Protein C, inactivator of coagulation factors Va and VIIIa.
  
  0.883
LOC100721435
Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
  
 0.742
F2
Coagulation factor II, thrombin; Belongs to the peptidase S1 family.
  
 0.727
CELA1
Chymotrypsin like elastase 1; Belongs to the peptidase S1 family.
   
 0.724
VTN
SMB domain-containing protein.
   
 0.698
FGB
Fibrinogen beta chain.
   
 0.694
FGG
Fibrinogen gamma chain.
   
 0.681
Alb
Preproalbumin.
   
 0.638
APOH
Apolipoprotein H.
   
 0.633
HPX
Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
   
 0.603
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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