STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gloHIsopropyl malate synthase gloH; 2-isopropylmalate synthase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non- competitive inhibition of beta-1,3-glucan synthase. The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4. The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain. The 10R,12S- dimethylmyristic acid is then transferred to the first thiolation domain of the [...] (617 aa)    
Predicted Functional Partners:
GLAREA_01994
3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 
 0.976
GLAREA_00709
IlvD/EDD N-terminal.
  
 
 0.968
GLAREA_09854
IlvD/EDD N-terminal.
  
 
 0.968
GLAREA_00197
Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.957
gloG
Branched-chain amino acid aminotransferase gloG; Branched-chain amino acid aminotransferase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non-competitive inhibition of beta-1,3-glucan synthase. The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4. The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain. The 10R,12S-dimethylmyristic acid is then transferred to the [...]
  
 0.953
GLAREA_00267
D-aminoacid aminotransferase-like PLP-dependent enzyme.
  
 0.943
GLAREA_11225
Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.943
GLAREA_10192
Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.943
GLAREA_03609
Acetyl-coenzyme A synthetase.
  
 
 0.930
GLAREA_04174
Thiolase-like protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.922
Your Current Organism:
Glarea lozoyensis
NCBI taxonomy Id: 1116229
Other names: G. lozoyensis ATCC 20868, Glarea lozoyensis ATCC 20868
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