STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gloGBranched-chain amino acid aminotransferase gloG; Branched-chain amino acid aminotransferase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non-competitive inhibition of beta-1,3-glucan synthase. The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4. The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain. The 10R,12S-dimethylmyristic acid is then transferred to the [...] (358 aa)    
Predicted Functional Partners:
GLAREA_00709
IlvD/EDD N-terminal.
  
 0.966
GLAREA_09854
IlvD/EDD N-terminal.
  
 0.966
gloH
Isopropyl malate synthase gloH; 2-isopropylmalate synthase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non- competitive inhibition of beta-1,3-glucan synthase. The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4. The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain. The 10R,12S- dimethylmyristic acid is then transferred to the first thiolation domain of the [...]
  
 0.953
GLAREA_01501
Thiamin diphosphate-binding fold (THDP-binding).
  
 0.946
GLAREA_02306
Aldolase.
  
 0.943
GLAREA_02572
Thiamin diphosphate-binding fold (THDP-binding).
  
 
 0.937
GLAREA_01485
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate.
    
 0.936
GLAREA_05647
PLP-dependent transferase.
   
 0.906
GLAREA_03336
NAD(P)-linked oxidoreductase.
    
  0.901
GLAREA_00509
Glutamine synthetase/guanido kinase.
     
  0.900
Your Current Organism:
Glarea lozoyensis
NCBI taxonomy Id: 1116229
Other names: G. lozoyensis ATCC 20868, Glarea lozoyensis ATCC 20868
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