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TriadP22834 protein (Trichoplax adhaerens) - STRING interaction network
"TriadP22834" - DNA topoisomerase in Trichoplax adhaerens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TriadP22834DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (625 aa)    
Predicted Functional Partners:
TriadP30770
annotation not available (752 aa)
   
  0.998
TriadP56278
annotation not available (507 aa)
     
  0.998
TriadP26257
annotation not available (642 aa)
     
  0.992
TriadP61244
annotation not available (480 aa)
   
 
  0.961
TriadP28563
annotation not available (160 aa)
     
 
  0.940
TriadP26121
annotation not available (326 aa)
   
 
  0.939
TriadP50671
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (556 aa)
     
  0.937
TriadP50503
annotation not available (846 aa)
   
 
  0.921
TriadP30199
annotation not available (560 aa)
     
 
  0.918
TriadP27976
annotation not available (687 aa)
   
 
  0.909
Your Current Organism:
Trichoplax adhaerens
NCBI taxonomy Id: 10228
Other names: T. adhaerens, Trichoplax adhaerens
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