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TriadP49643 protein (Trichoplax adhaerens) - STRING interaction network
"TriadP49643" - DNA topoisomerase in Trichoplax adhaerens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TriadP49643DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (841 aa)    
Predicted Functional Partners:
TriadP30770
annotation not available (752 aa)
   
  0.955
TriadP56278
annotation not available (507 aa)
     
  0.955
TriadP60006
annotation not available (237 aa)
     
 
  0.942
TriadP26257
annotation not available (642 aa)
     
  0.890
TriadP61244
annotation not available (480 aa)
   
 
  0.871
TriadP22834
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (625 aa)
   
 
0.839
TriadP30199
annotation not available (560 aa)
     
 
  0.838
TriadP23201
DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (1164 aa)
     
 
  0.836
TriadP57881
annotation not available (130 aa)
         
    0.800
TriadP50671
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (556 aa)
     
  0.766
Your Current Organism:
Trichoplax adhaerens
NCBI taxonomy Id: 10228
Other names: T. adhaerens, Trichoplax adhaerens
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