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TriadP50671 protein (Trichoplax adhaerens) - STRING interaction network
"TriadP50671" - Replication protein A subunit in Trichoplax adhaerens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
TriadP50671Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (556 aa)    
Predicted Functional Partners:
TriadP32825
annotation not available (140 aa)
     
  0.976
TriadP30770
annotation not available (752 aa)
     
  0.954
TriadP22834
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (625 aa)
     
  0.937
TriadP50695
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (261 aa)
     
 
  0.931
TriadP35366
annotation not available (670 aa)
     
 
  0.926
TriadP63837
annotation not available (904 aa)
     
 
  0.925
TriadP56278
annotation not available (507 aa)
     
  0.919
TriadP19118
annotation not available (714 aa)
     
 
  0.909
TriadP28563
annotation not available (160 aa)
     
 
  0.892
TriadP18979
annotation not available (1050 aa)
     
 
  0.889
Your Current Organism:
Trichoplax adhaerens
NCBI taxonomy Id: 10228
Other names: T. adhaerens, Trichoplax adhaerens
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