node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
all1368 | all3263 | gene:10493383 | gene:10495301 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
all1368 | alr1965 | gene:10493383 | gene:10493984 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.972 |
all1368 | hisA | gene:10493383 | gene:10496555 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:all4506. | 0.999 |
all1368 | hisB-2 | gene:10493383 | gene:10496439 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Imidazoleglycerol-phosphate dehydratase; ORF_ID:all4390. | 0.997 |
all1368 | hisC | gene:10493383 | gene:10494121 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Histidinol phosphate aminotransferase; ORF_ID:alr2092; hisC gene product; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.937 |
all1368 | hisC-2 | gene:10493383 | gene:10495978 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Histidinol-phosphate aminotransferase; ORF_ID:alr3936. | 0.934 |
all1368 | hisC-3 | gene:10493383 | gene:10497021 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Histidinol-phosphate aminotransferase; ORF_ID:all4966; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.917 |
all1368 | hisD | gene:10493383 | gene:10493607 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.960 |
all1368 | hisD-2 | gene:10493383 | gene:10495092 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.960 |
all1368 | hisF | gene:10493383 | gene:10494930 | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
all3263 | all1368 | gene:10495301 | gene:10493383 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
all3263 | alr1965 | gene:10495301 | gene:10493984 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
all3263 | hisA | gene:10495301 | gene:10496555 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:all4506. | 0.999 |
all3263 | hisB-2 | gene:10495301 | gene:10496439 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | Imidazoleglycerol-phosphate dehydratase; ORF_ID:all4390. | 0.999 |
all3263 | hisC | gene:10495301 | gene:10494121 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | Histidinol phosphate aminotransferase; ORF_ID:alr2092; hisC gene product; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.996 |
all3263 | hisC-2 | gene:10495301 | gene:10495978 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | Histidinol-phosphate aminotransferase; ORF_ID:alr3936. | 0.996 |
all3263 | hisC-3 | gene:10495301 | gene:10497021 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | Histidinol-phosphate aminotransferase; ORF_ID:all4966; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.996 |
all3263 | hisD | gene:10495301 | gene:10493607 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
all3263 | hisD-2 | gene:10495301 | gene:10495092 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
all3263 | hisF | gene:10495301 | gene:10494930 | Histidine biosynthesis bifunctional protein; ORF_ID:all3263; In the C-terminal section; belongs to the PRA-PH family. | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |