STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
pigHGlycine C-acetyltransferase; Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5- carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Carrier of the L- malonyl group (malonyl-S-PigH), which is decarboxylated by PigJ to yield a C2 carbanion acetyl-S-PigH. Then the pyrrolyl group of pyrrolyl-S-cysteinyl PigJ intermediate is captured by the C2 carbanion acetyl-S-PigH to yield the pyrrolyl-beta-ketoacyl-S-PigH. In the last step, PigH catalyzes the decarboxylative condensation between the pyrrolyl-beta-ketoacyl (pyrro [...] (653 aa)    
Predicted Functional Partners:
tdh
L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family.
 
 
 0.910
ESN64553.1
Aspartate racemase; KEGG: amino acid adenylation domain-containing protein.
  
 
 0.865
pigM
Hypothetical protein; Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5- carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the oxidation of the hydroxy group of 4-hydroxy-2,2'-bipyrrole-5-methanol (HBM) to yield 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC). Belongs to the nitroreductase family.
    
 0.854
pigJ
Beta-ketoacyl-acyl-carrier-protein synthase I; Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5- carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the decarboxylation on the malonyl group attached to PigH to yield a C2 carbanion of acetyl-S-PigH. Then, the heterocyclic pyrrole group of PigG moves to the PigJ active site Cys-525 to generate a transient pyrrolyl-S-cysteinyl PigJ intermediate (acyl donor) whose pyrrolyl group is captured by the C2 carbanion of acetyl-S-PigH to yield the pyrrolyl-beta- [...]
   
 0.852
ESN64556.1
Phenylalanine racemase (ATP-hydrolyzing); KEGG: amino acid adenylation protein.
 
 
 0.850
pigG
Hypothetical protein; Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5- carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Carrier of the L- prolyl group transferred from L-prolyl-AMP by PigI.
  
 
 0.841
bioD-2
Hypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family.
 
 
 0.841
pigE
Acetylornithine transaminase; Involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the transamination to the aldehyde group of 3-acetyloctanal, resulting in an aminoketone, which spontaneously cyclizes to yield the dihydro form of MAP (H2MAP).
    
 0.835
pigI
D-alanine--poly(phosphoribitol) ligase; Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5- carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the conversion of L-proline to L-prolyl-AMP and the transfer of the L-prolyl group to acyl carrier protein PigG ; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 
 0.832
birA
Biotin--(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
  
 
 0.827
Your Current Organism:
Serratia sp. ATCC 39006
NCBI taxonomy Id: 104623
Other names: S. sp. ATCC 39006
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