egf protein (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

egf

Epidermal growth factor. (979 aa)

Predicted Functional Partners:

erbb2

0.884

LOC109530291

0.847

egfr

0.847

grb2

0.831

tgfa

0.830

ENSHCOP00000003178

0.829

LOC109527848

0.796

erbb3

0.795

LOC109531201

0.795

erbb4

0.795

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000003178	LOC109527848	ENSHCOP00000003178	ENSHCOP00000016408	Uncharacterized protein.	EGF-like domain-containing protein.	0.784
ENSHCOP00000003178	LOC109530291	ENSHCOP00000003178	ENSHCOP00000010454	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.671
ENSHCOP00000003178	LOC109531201	ENSHCOP00000003178	ENSHCOP00000006797	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.671
ENSHCOP00000003178	egf	ENSHCOP00000003178	ENSHCOP00000021699	Uncharacterized protein.	Epidermal growth factor.	0.829
ENSHCOP00000003178	egfr	ENSHCOP00000003178	ENSHCOP00000013969	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.671
ENSHCOP00000003178	erbb2	ENSHCOP00000003178	ENSHCOP00000026327	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.671
ENSHCOP00000003178	erbb3	ENSHCOP00000003178	ENSHCOP00000002166	Uncharacterized protein.	Protein kinase domain-containing protein.	0.671
ENSHCOP00000003178	erbb4	ENSHCOP00000003178	ENSHCOP00000007760	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.671
ENSHCOP00000003178	grb2	ENSHCOP00000003178	ENSHCOP00000021807	Uncharacterized protein.	Growth factor receptor-bound protein 2b.	0.522
ENSHCOP00000003178	tgfa	ENSHCOP00000003178	ENSHCOP00000014364	Uncharacterized protein.	Transforming growth factor, alpha.	0.767
LOC109527848	ENSHCOP00000003178	ENSHCOP00000016408	ENSHCOP00000003178	EGF-like domain-containing protein.	Uncharacterized protein.	0.784
LOC109527848	LOC109530291	ENSHCOP00000016408	ENSHCOP00000010454	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.579
LOC109527848	LOC109531201	ENSHCOP00000016408	ENSHCOP00000006797	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.501
LOC109527848	egf	ENSHCOP00000016408	ENSHCOP00000021699	EGF-like domain-containing protein.	Epidermal growth factor.	0.796
LOC109527848	egfr	ENSHCOP00000016408	ENSHCOP00000013969	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.657
LOC109527848	erbb2	ENSHCOP00000016408	ENSHCOP00000026327	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.501
LOC109527848	erbb3	ENSHCOP00000016408	ENSHCOP00000002166	EGF-like domain-containing protein.	Protein kinase domain-containing protein.	0.501
LOC109527848	erbb4	ENSHCOP00000016408	ENSHCOP00000007760	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.501
LOC109527848	grb2	ENSHCOP00000016408	ENSHCOP00000021807	EGF-like domain-containing protein.	Growth factor receptor-bound protein 2b.	0.525
LOC109527848	tgfa	ENSHCOP00000016408	ENSHCOP00000014364	EGF-like domain-containing protein.	Transforming growth factor, alpha.	0.632