STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gtf1Glycosyltransferase; Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in the substrate protein. Part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. (504 aa)    
Predicted Functional Partners:
gtf2
Glycosyltransferase; Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. A stabilizing protein that is part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. The GtfA-GtfB complex adds GlcNAc from UDP-GlcNAc to the substrate protein, attaching the first sugar residue. Stabilizes the glycosylation activity of GtfA. Has no N-acetylglucosaminyl transferase activity on its own.
 
 
 0.998
gap3
Glycosylation associated protein, mature Fap1 export and glycosylation,gap3.
 
 
 
 0.988
gap2
Glycosylation associated protein, mature Fap1 export and glycosylation,gap2.
 
 
 
 0.985
gap1
Glycosylation associated protein, mature Fap1 export and glycosylation,gap1.
 
   
 0.972
secY2
Preprotein translocase subunit SecY2; Part of the accessory SecA2/SecY2 system specifically required for export of possible cell wall proteins. The central subunit of a protein translocation channel.
 
   
 0.912
secA2
Preprotein translocase subunit SecA2; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
 
   
 0.908
fap1
Fimbriae-associated protein Fap1 (fap1).
 
   
 0.892
nss
Nucleotide sugar synthetase-like protein (nss).
 
   
 0.891
prgA
Surface exclusion protein PrgA.
  
 
 0.700
glgB
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
   
 0.697
Your Current Organism:
Streptococcus parasanguinis
NCBI taxonomy Id: 1114965
Other names: S. parasanguinis FW213, Streptococcus parasanguinis FW213, Streptococcus parasanguinis str. FW213, Streptococcus parasanguinis strain FW213
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.