STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dsat_1118MGS domain protein; KEGG: dde:Dde_0377 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein, AICARFT/IMPCHase bienzyme; SMART: MGS domain protein. (199 aa)    
Predicted Functional Partners:
purL
Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
  
 
 0.998
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 0.997
dsat_1804
AICARFT/IMPCHase bienzyme; KEGG: dma:DMR_03270 putative phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme; SMART: AICARFT/IMPCHase bienzyme.
  
  0.992
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 0.980
purD
TIGRFAM: phosphoribosylamine/glycine ligase; HAMAP : Phosphoribosylamine--glycine ligase; KEGG: dsa:Desal_3434 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain-containing protein, Phosphoribosylglycinamide synthetase, N-domain-containing protein, Phosphoribosylglycinamide synthetase, C-domain-containing protein; Belongs to the GARS family.
 
 0.972
dsat_1702
TIGRFAM: adenylosuccinate lyase; PFAM: Lyase 1, N-terminal, Adenylosuccinate lyase; KEGG: dvm:DvMF_1468 adenylosuccinate lyase; SMART: Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.958
dsat_1413
KEGG: dsa:Desal_2262 phosphoribosylformylglycinamidine synthase.
 
 
 0.955
purM
KEGG: dba:Dbac_0046 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein, AIR synthase related protein.
 
  
 0.953
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.951
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.947
Your Current Organism:
Desulfovibrio alkalitolerans
NCBI taxonomy Id: 1121439
Other names: D. alkalitolerans DSM 16529, Desulfovibrio alkalitolerans DSM 16529
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