STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
valBNucleotidylyltransferase; Involved in the biosynthesis of the antifungal agent validamycin A. Catalyzes the conversion of valienol 1-phosphate to GDP-valienol. Also able to use efficiently ATP as nucleotidyl donor, but other NDP derivatives are less efficient ; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (373 aa)    
Predicted Functional Partners:
glgB
Putative 1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
 
  
 0.947
glgB-2
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
 
  
 0.947
SHJG_2722
Glycoside hydrolase.
 
  
 0.944
valL
Validoxylamine synthase; Involved in the biosynthesis of the antifungal agent validamycin A. Catalyzes the condensation between GDP-valienol and validamine 7-phosphate via a nonglycosidic C-N bond formation to yield validoxylamine A 7'-phosphate. Belongs to the glycosyltransferase 20 family.
    
 0.933
SHJG_6522
Glycogen phosphorylase.
 
  
 0.923
SHJG_7153
Alpha-amylase.
 
  
 0.874
valC
Cyclitol kinase; Involved in the biosynthesis of the antifungal agent validamycin A. Catalyzes the phosphorylation of valienone and validone to their 7-phosphate derivatives.
 
   
 0.847
argG
Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
  
 0.841
SHJG_6538
Glycogen debranching enzyme; Belongs to the glycosyl hydrolase 13 family.
 
  
 0.837
SHJG_2095
Glycogen debranching enzyme; Belongs to the glycosyl hydrolase 13 family.
 
  
 0.821
Your Current Organism:
Streptomyces hygroscopicus jinggangensis
NCBI taxonomy Id: 1133850
Other names: S. hygroscopicus subsp. jinggangensis 5008, Streptomyces hygroscopicus subsp. jinggangensis 5008, Streptomyces hygroscopicus subsp. jinggangensis str. 5008, Streptomyces hygroscopicus subsp. jinggangensis strain 5008
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