node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRADO0306 | cobB | BRADO0306 | BRADO4897 | Function of strongly homologous gene; putative regulator; Belongs to the P(II) protein family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.418 |
BRADO0306 | glnA | BRADO0306 | BRADO4205 | Function of strongly homologous gene; putative regulator; Belongs to the P(II) protein family. | Glutamine synthetase I (Glutamate--ammonia ligase I) (GSI); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.435 |
BRADO0306 | glnD | BRADO0306 | BRADO0530 | Function of strongly homologous gene; putative regulator; Belongs to the P(II) protein family. | [Protein-PII] uridylyltransferase (PII uridylyl-transferase) (Uridylyl-removing enzyme) (UTase); Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regul [...] | 0.784 |
BRADO0306 | glnE | BRADO0306 | BRADO2744 | Function of strongly homologous gene; putative regulator; Belongs to the P(II) protein family. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.416 |
BRADO0306 | gltB | BRADO0306 | BRADO6238 | Function of strongly homologous gene; putative regulator; Belongs to the P(II) protein family. | Glutamate synthase [NADPH] large chain (NADPH-GOGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.602 |
BRADO0306 | ntrB | BRADO0306 | BRADO3867 | Function of strongly homologous gene; putative regulator; Belongs to the P(II) protein family. | Nitrogen regulation protein; Function of homologous gene experimentally demonstrated in an other organism; regulator. | 0.774 |
BRADO0529 | glnD | BRADO0529 | BRADO0530 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | [Protein-PII] uridylyltransferase (PII uridylyl-transferase) (Uridylyl-removing enzyme) (UTase); Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regul [...] | 0.499 |
BRADO0531 | glnD | BRADO0531 | BRADO0530 | Putative sulfonate ABC transporter, periplasmic binding protein (ssuA/ycbO-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | [Protein-PII] uridylyltransferase (PII uridylyl-transferase) (Uridylyl-removing enzyme) (UTase); Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regul [...] | 0.548 |
cobB | BRADO0306 | BRADO4897 | BRADO0306 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Function of strongly homologous gene; putative regulator; Belongs to the P(II) protein family. | 0.418 |
cobB | glnB | BRADO4897 | BRADO4204 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Nitrogen regulatory protein P-II; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | 0.406 |
cobB | glnD | BRADO4897 | BRADO0530 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | [Protein-PII] uridylyltransferase (PII uridylyl-transferase) (Uridylyl-removing enzyme) (UTase); Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regul [...] | 0.552 |
cobB | glnK1 | BRADO4897 | BRADO0308 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Nitrogen regulatory protein P-II 2; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | 0.418 |
glnA | BRADO0306 | BRADO4205 | BRADO0306 | Glutamine synthetase I (Glutamate--ammonia ligase I) (GSI); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Function of strongly homologous gene; putative regulator; Belongs to the P(II) protein family. | 0.435 |
glnA | glnB | BRADO4205 | BRADO4204 | Glutamine synthetase I (Glutamate--ammonia ligase I) (GSI); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Nitrogen regulatory protein P-II; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | 0.722 |
glnA | glnD | BRADO4205 | BRADO0530 | Glutamine synthetase I (Glutamate--ammonia ligase I) (GSI); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | [Protein-PII] uridylyltransferase (PII uridylyl-transferase) (Uridylyl-removing enzyme) (UTase); Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regul [...] | 0.538 |
glnA | glnE | BRADO4205 | BRADO2744 | Glutamine synthetase I (Glutamate--ammonia ligase I) (GSI); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.742 |
glnA | glnK1 | BRADO4205 | BRADO0308 | Glutamine synthetase I (Glutamate--ammonia ligase I) (GSI); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Nitrogen regulatory protein P-II 2; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | 0.438 |
glnA | gltB | BRADO4205 | BRADO6238 | Glutamine synthetase I (Glutamate--ammonia ligase I) (GSI); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Glutamate synthase [NADPH] large chain (NADPH-GOGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.976 |
glnB | cobB | BRADO4204 | BRADO4897 | Nitrogen regulatory protein P-II; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.406 |
glnB | glnA | BRADO4204 | BRADO4205 | Nitrogen regulatory protein P-II; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | Glutamine synthetase I (Glutamate--ammonia ligase I) (GSI); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.722 |