node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRADO0221 | def | BRADO0221 | BRADO0770 | Putative enzyme (N-terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Peptide deformylase (PDF) (Polypeptide deformylase); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.476 |
BRADO0221 | recA | BRADO0221 | BRADO4985 | Putative enzyme (N-terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Recombinase A (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.471 |
BRADO0221 | ruvA | BRADO0221 | BRADO1145 | Putative enzyme (N-terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.513 |
BRADO0221 | ruvB | BRADO0221 | BRADO1147 | Putative enzyme (N-terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Holliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.470 |
BRADO0221 | ruvC | BRADO0221 | BRADO1144 | Putative enzyme (N-terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Crossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC); Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.760 |
BRADO1143 | BRADO1146 | BRADO1143 | BRADO1146 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Cytidine deaminase family enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.491 |
BRADO1143 | ruvA | BRADO1143 | BRADO1145 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.765 |
BRADO1143 | ruvB | BRADO1143 | BRADO1147 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Holliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.793 |
BRADO1143 | ruvC | BRADO1143 | BRADO1144 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Crossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC); Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.747 |
BRADO1146 | BRADO1143 | BRADO1146 | BRADO1143 | Cytidine deaminase family enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.491 |
BRADO1146 | polA | BRADO1146 | BRADO0752 | Cytidine deaminase family enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.412 |
BRADO1146 | ruvA | BRADO1146 | BRADO1145 | Cytidine deaminase family enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.653 |
BRADO1146 | ruvB | BRADO1146 | BRADO1147 | Cytidine deaminase family enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Holliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.787 |
BRADO1146 | ruvC | BRADO1146 | BRADO1144 | Cytidine deaminase family enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Crossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC); Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.709 |
BRADO4647 | ruvC | BRADO4647 | BRADO1144 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Crossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC); Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.624 |
BRADO4942 | polA | BRADO4942 | BRADO0752 | Hypothetical protein; No homology to any previously reported sequences. | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.690 |
BRADO4942 | recA | BRADO4942 | BRADO4985 | Hypothetical protein; No homology to any previously reported sequences. | Recombinase A (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.691 |
BRADO4942 | ruvA | BRADO4942 | BRADO1145 | Hypothetical protein; No homology to any previously reported sequences. | Holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.962 |
BRADO4942 | ruvC | BRADO4942 | BRADO1144 | Hypothetical protein; No homology to any previously reported sequences. | Crossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC); Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.809 |
def | BRADO0221 | BRADO0770 | BRADO0221 | Peptide deformylase (PDF) (Polypeptide deformylase); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Putative enzyme (N-terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | 0.476 |