Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Hypothetical protein (206 aa)
Predicted Functional Partners:
Hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin (150 aa)
Hypothetical protein (139 aa)
Beta-glucosidase (538 aa)
RecF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication. RecF binds preferentially to single- stranded, linear DNA. It also seems to bind ATP (By similarity) (384 aa)