STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysGuroporphyrin-III C-methyltransferase; Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin. (263 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.985
hemD
uroporphyrin-III synthase; ORF_ID:sll0166; Belongs to the precorrin methyltransferase family.
 
 
0.948
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.943
cbiL
S-adenosyl-methionine: precorrin-2 methyltransferase; ORF_ID:slr1879; gene:cbiL or cobI; Belongs to the precorrin methyltransferase family.
  
 
 0.917
nirA
Ferredoxin--nitrite reductase; ORF_ID:slr0898; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.907
cysH
3'-phosphoadenosine-5'-phosphosulfate sulfotransferase; Reduction of activated sulfate into sulfite; Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.900
sll0037
Sirohydrochlorin cobaltochelatase; Chelates cobalt to the cobalamin precursor as part of the anaerobic pathway to cobalamin biosynthesis.
 
  
 0.885
sir
Ferredoxin-sulfite reductase; Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.880
hemB
Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
 
  
 0.857
cobU
Cobinamide kinase/cobinamide phosphate guanylyltransferase; ORF_ID:slr0216; gene:cobU or cobP.
 
  
 0.808
Your Current Organism:
Synechocystis sp. PCC6803
NCBI taxonomy Id: 1148
Other names: Aphanocapsa sp. (strain N-1), Aphanocapsa sp. N-1, S. sp. PCC 6803, Synechocystis sp. (ATCC 27184), Synechocystis sp. (PCC 6803), Synechocystis sp. (strain PCC 6803), Synechocystis sp. ATCC 27184, Synechocystis sp. PCC 6803, Synechocystis sp. PCC 6803 A, Synechocystis sp. PCC 6803 B
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