node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folC | folE | gene:10498768 | gene:10499907 | Folyl-polyglutamate synthetase; ORF_ID:sll1612; gene:folC or dedC; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | 0.823 |
folC | folK | gene:10498768 | gene:10497606 | Folyl-polyglutamate synthetase; ORF_ID:sll1612; gene:folC or dedC; Belongs to the folylpolyglutamate synthase family. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; ORF_ID:slr1093; Belongs to the HPPK family. | 0.950 |
folC | folP | gene:10498768 | gene:10498138 | Folyl-polyglutamate synthetase; ORF_ID:sll1612; gene:folC or dedC; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate pyrophosphorylase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. | 0.997 |
folC | slr0651 | gene:10498768 | gene:10500433 | Folyl-polyglutamate synthetase; ORF_ID:sll1612; gene:folC or dedC; Belongs to the folylpolyglutamate synthase family. | ORF_ID:slr0651; unknown protein. | 0.544 |
folC | slr1626 | gene:10498768 | gene:10499312 | Folyl-polyglutamate synthetase; ORF_ID:sll1612; gene:folC or dedC; Belongs to the folylpolyglutamate synthase family. | Probable dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.720 |
folE | folC | gene:10499907 | gene:10498768 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | Folyl-polyglutamate synthetase; ORF_ID:sll1612; gene:folC or dedC; Belongs to the folylpolyglutamate synthase family. | 0.823 |
folE | folK | gene:10499907 | gene:10497606 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; ORF_ID:slr1093; Belongs to the HPPK family. | 0.998 |
folE | folP | gene:10499907 | gene:10498138 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | Dihydropteroate pyrophosphorylase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. | 0.944 |
folE | moaA | gene:10499907 | gene:10499952 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.910 |
folE | ndkR | gene:10499907 | gene:10499478 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.843 |
folE | ribA | gene:10499907 | gene:10499063 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.951 |
folE | slr0078 | gene:10499907 | gene:10500054 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | 6-carboxy-5,6,7,8-tetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. | 0.991 |
folE | slr0651 | gene:10499907 | gene:10500433 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | ORF_ID:slr0651; unknown protein. | 0.827 |
folE | slr1626 | gene:10499907 | gene:10499312 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | Probable dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.994 |
folE | spoT | gene:10499907 | gene:10498949 | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | (p)ppGpp 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family. | 0.817 |
folK | folC | gene:10497606 | gene:10498768 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; ORF_ID:slr1093; Belongs to the HPPK family. | Folyl-polyglutamate synthetase; ORF_ID:sll1612; gene:folC or dedC; Belongs to the folylpolyglutamate synthase family. | 0.950 |
folK | folE | gene:10497606 | gene:10499907 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; ORF_ID:slr1093; Belongs to the HPPK family. | GTP cyclohydrolase I; ORF_ID:slr0426; gene:folE or gchL. | 0.998 |
folK | folP | gene:10497606 | gene:10498138 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; ORF_ID:slr1093; Belongs to the HPPK family. | Dihydropteroate pyrophosphorylase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. | 0.999 |
folK | ribA | gene:10497606 | gene:10499063 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; ORF_ID:slr1093; Belongs to the HPPK family. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.634 |
folK | slr0651 | gene:10497606 | gene:10500433 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; ORF_ID:slr1093; Belongs to the HPPK family. | ORF_ID:slr0651; unknown protein. | 0.827 |