node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB-2 | gene:10500434 | gene:10500075 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | 0.991 |
hisA | hisD | gene:10500434 | gene:10497823 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | Histidinol dehydrogenase; ORF_ID:slr0682; Belongs to the histidinol dehydrogenase family. | 0.958 |
hisA | hisD-2 | gene:10500434 | gene:10497941 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.959 |
hisA | hisF | gene:10500434 | gene:10499065 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.997 |
hisA | hisG | gene:10500434 | gene:10500361 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.986 |
hisA | hisH | gene:10500434 | gene:10500062 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | N-acetyl-glutamate-gamma-semialdehyde dehydrogenase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | gene:10500434 | gene:10500647 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | phosphoribosyl-ATP pyrophosphohydrolase:phosphoribosyl-AMP cyclohydrolase; ORF_ID:slr0608; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | hisS-2 | gene:10500434 | gene:10500472 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | Histidyl tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.936 |
hisA | trpC | gene:10500434 | gene:10500369 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | Indole-3-glycerol phosphate synthase; ORF_ID:slr0546; Belongs to the TrpC family. | 0.937 |
hisA | trpF | gene:10500434 | gene:10499418 | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | 5'-phosphoribosyl anthranilate isomerase; ORF_ID:sll0356; Belongs to the TrpF family. | 0.936 |
hisB-2 | hisA | gene:10500075 | gene:10500434 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | 0.991 |
hisB-2 | hisD | gene:10500075 | gene:10497823 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | Histidinol dehydrogenase; ORF_ID:slr0682; Belongs to the histidinol dehydrogenase family. | 0.963 |
hisB-2 | hisD-2 | gene:10500075 | gene:10497941 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisB-2 | hisF | gene:10500075 | gene:10499065 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisB-2 | hisG | gene:10500075 | gene:10500361 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.987 |
hisB-2 | hisH | gene:10500075 | gene:10500062 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | N-acetyl-glutamate-gamma-semialdehyde dehydrogenase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.998 |
hisB-2 | hisI | gene:10500075 | gene:10500647 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | phosphoribosyl-ATP pyrophosphohydrolase:phosphoribosyl-AMP cyclohydrolase; ORF_ID:slr0608; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisB-2 | hisS-2 | gene:10500075 | gene:10500472 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | Histidyl tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.949 |
hisB-2 | trpC | gene:10500075 | gene:10500369 | Imidazoleglycerol-phosphate dehydratase; ORF_ID:slr0500. | Indole-3-glycerol phosphate synthase; ORF_ID:slr0546; Belongs to the TrpC family. | 0.402 |
hisD | hisA | gene:10497823 | gene:10500434 | Histidinol dehydrogenase; ORF_ID:slr0682; Belongs to the histidinol dehydrogenase family. | Phosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; ORF_ID:slr0652. | 0.958 |