STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menH2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC); Belongs to the AB hydrolase superfamily. MenH family. (272 aa)    
Predicted Functional Partners:
menD
2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
 
 0.997
menC
O-succinylbenzoic acid (OSB) synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
  
  0.988
AFZ14674.1
Isochorismate synthase; PFAM: chorismate binding enzyme; COGs: COG1169 Isochorismate synthase; InterPro IPR015890:IPR004561; KEGG: ava:Ava_2632 menaquinone-specific isochorismate synthase; PFAM: Chorismate binding, C-terminal; PRIAM: Isochorismate synthase; SPTR: Isochorismate synthases; TIGRFAM: Isochorismate synthase.
  
  0.957
menB
1,4-Dihydroxy-2-naphthoyl-CoA synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
   
 0.919
AFZ14679.1
o-succinylbenzoate--CoA ligase; PFAM: AMP-binding enzyme; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873; KEGG: ava:Ava_2636 O-succinylbenzoic acid--CoA ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: o-succinylbenzoate--CoA ligase; SPTR: AMP-dependent synthetase and ligase.
 
   0.898
menA
1,4-dihydroxy-2-naphthoate phytyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily.
 
 
 
 0.684
menG
Demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of 2-phytyl- 1,4-beta-naphthoquinol to phylloquinol.
 
     0.646
AFZ11726.1
COGs: COG0596 hydrolase or acyltransferase (alpha/beta hydrolase superfamily); InterPro IPR000073; KEGG: ava:Ava_4708 alpha/beta hydrolase fold; PFAM: Alpha/beta hydrolase fold-1; SPTR: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase.
  
     0.636
AFZ12486.1
Amino acid adenylation domain protein; PFAM: Male sterility protein; Phosphopantetheine attachment site; Methyltransferase domain; AMP-binding enzyme; Condensation domain; PilZ domain; TIGRFAM: amino acid adenylation domain; thioester reductase domain; COGs: COG1020 Non-ribosomal peptide synthetase modules and related protein; InterProIPR020806:IPR000873:IPR013217:IPR006163:IPR 001242:IPR009875:IPR013120:IPR010071:IPR010080; KEGG: npu:Npun_CR072 amino acid adenylation domain-containing protein; PFAM: AMP-dependent synthetase/ligase; Methyltransferase type 12; Phosphopantetheine-binding [...]
   
 
 0.585
AFZ15023.1
COGs: COG0596 hydrolase or acyltransferase (alpha/beta hydrolase superfamily); InterPro IPR000073; KEGG: ava:Ava_2037 alpha/beta hydrolase fold; PFAM: Alpha/beta hydrolase fold-1; SPTR: Alpha/beta hydrolase fold protein.
  
     0.573
Your Current Organism:
Crinalium epipsammum
NCBI taxonomy Id: 1173022
Other names: C. epipsammum PCC 9333, Crinalium epipsammum PCC 9333, Crinalium sp. PCC 9333
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