node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFZ30583.1 | AFZ31579.1 | Glo7428_2039 | Glo7428_3092 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | PFAM: FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: rop:ROP_25440 putative oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: Putative oxidoreductase. | 0.911 |
AFZ30583.1 | AFZ31676.1 | Glo7428_2039 | Glo7428_3189 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027:IPR004099:IPR006258; KEGG: npu:Npun_R4179 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: [...] | 0.901 |
AFZ30583.1 | AFZ32969.1 | Glo7428_2039 | Glo7428_4530 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase class I and II; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: cyc:PCC7424_2980 aminotransferase class I and II; PFAM: Aminotransferase, class I/II; PRIAM: 8-amino-7-oxononanoate synthase; SPTR: Aminotransferase, classes I and II superfamily. | 0.908 |
AFZ30583.1 | gcvH | Glo7428_2039 | Glo7428_3657 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.914 |
AFZ30583.1 | gcvP | Glo7428_2039 | Glo7428_3656 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.934 |
AFZ30583.1 | gcvT | Glo7428_2039 | Glo7428_3658 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.931 |
AFZ30583.1 | glyA | Glo7428_2039 | Glo7428_2937 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
AFZ30583.1 | purD | Glo7428_2039 | Glo7428_1160 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; COGs: COG0151 Phosphoribosylamine-glycine ligase; HAMAP: Phosphoribosylglycinamide synthetase; InterPro IPR020562:IPR020561:IPR020560:IPR000115; KEGG: ava:Ava_3227 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthe [...] | 0.589 |
AFZ31138.1 | AFZ31676.1 | Glo7428_2636 | Glo7428_3189 | PFAM: ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650:IPR005811; KEGG: ava:Ava_1783 succinyl-CoA synthetase (ADP-forming) beta subunit; PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; ATP-citrate lyase/succinyl-CoA ligase; PRIAM: Succinate--CoA ligase (ADP-forming); SPTR: Succinyl-CoA synthetase (ADP-forming) beta subunit. | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027:IPR004099:IPR006258; KEGG: npu:Npun_R4179 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: [...] | 0.486 |
AFZ31138.1 | AFZ32052.1 | Glo7428_2636 | Glo7428_3583 | PFAM: ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650:IPR005811; KEGG: ava:Ava_1783 succinyl-CoA synthetase (ADP-forming) beta subunit; PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; ATP-citrate lyase/succinyl-CoA ligase; PRIAM: Succinate--CoA ligase (ADP-forming); SPTR: Succinyl-CoA synthetase (ADP-forming) beta subunit. | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR004439:IPR001804; KEGG: ana:alr1827 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: Isocitrate dehydrogenase [NADP]; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, prokaryotic. | 0.921 |
AFZ31138.1 | gcvP | Glo7428_2636 | Glo7428_3656 | PFAM: ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650:IPR005811; KEGG: ava:Ava_1783 succinyl-CoA synthetase (ADP-forming) beta subunit; PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; ATP-citrate lyase/succinyl-CoA ligase; PRIAM: Succinate--CoA ligase (ADP-forming); SPTR: Succinyl-CoA synthetase (ADP-forming) beta subunit. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.943 |
AFZ31138.1 | gcvT | Glo7428_2636 | Glo7428_3658 | PFAM: ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650:IPR005811; KEGG: ava:Ava_1783 succinyl-CoA synthetase (ADP-forming) beta subunit; PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; ATP-citrate lyase/succinyl-CoA ligase; PRIAM: Succinate--CoA ligase (ADP-forming); SPTR: Succinyl-CoA synthetase (ADP-forming) beta subunit. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.833 |
AFZ31579.1 | AFZ30583.1 | Glo7428_3092 | Glo7428_2039 | PFAM: FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: rop:ROP_25440 putative oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: Putative oxidoreductase. | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | 0.911 |
AFZ31579.1 | AFZ32969.1 | Glo7428_3092 | Glo7428_4530 | PFAM: FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: rop:ROP_25440 putative oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: Putative oxidoreductase. | 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase class I and II; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: cyc:PCC7424_2980 aminotransferase class I and II; PFAM: Aminotransferase, class I/II; PRIAM: 8-amino-7-oxononanoate synthase; SPTR: Aminotransferase, classes I and II superfamily. | 0.916 |
AFZ31579.1 | gcvP | Glo7428_3092 | Glo7428_3656 | PFAM: FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: rop:ROP_25440 putative oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: Putative oxidoreductase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.923 |
AFZ31579.1 | gcvT | Glo7428_3092 | Glo7428_3658 | PFAM: FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: rop:ROP_25440 putative oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: Putative oxidoreductase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.972 |
AFZ31579.1 | glyA | Glo7428_3092 | Glo7428_2937 | PFAM: FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: rop:ROP_25440 putative oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: Putative oxidoreductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.914 |
AFZ31676.1 | AFZ30583.1 | Glo7428_3189 | Glo7428_2039 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027:IPR004099:IPR006258; KEGG: npu:Npun_R4179 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: [...] | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: ana:alr1004 alanine--glyoxylate aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Serine--pyruvate transaminase; SPTR: Alanine--glyoxylate aminotransferase. | 0.901 |
AFZ31676.1 | AFZ31138.1 | Glo7428_3189 | Glo7428_2636 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027:IPR004099:IPR006258; KEGG: npu:Npun_R4179 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: [...] | PFAM: ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650:IPR005811; KEGG: ava:Ava_1783 succinyl-CoA synthetase (ADP-forming) beta subunit; PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; ATP-citrate lyase/succinyl-CoA ligase; PRIAM: Succinate--CoA ligase (ADP-forming); SPTR: Succinyl-CoA synthetase (ADP-forming) beta subunit. | 0.486 |
AFZ31676.1 | gcvH | Glo7428_3189 | Glo7428_3657 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027:IPR004099:IPR006258; KEGG: npu:Npun_R4179 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: [...] | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.987 |