node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFZ20337.1 | hisA | Mic7113_4664 | Mic7113_3289 | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | 0.893 |
AFZ20337.1 | hisB | Mic7113_4664 | Mic7113_2171 | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.926 |
AFZ20337.1 | hisD | Mic7113_4664 | Mic7113_5562 | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.939 |
AFZ20337.1 | hisF | Mic7113_4664 | Mic7113_2956 | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.915 |
AFZ20337.1 | hisG | Mic7113_4664 | Mic7113_3668 | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.890 |
AFZ20337.1 | hisH | Mic7113_4664 | Mic7113_4735 | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.931 |
AFZ20337.1 | hisI | Mic7113_4664 | Mic7113_3024 | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.896 |
AFZ20337.1 | hisI-2 | Mic7113_4664 | Mic7113_4800 | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.998 |
AFZ20337.1 | hisZ | Mic7113_4664 | Mic7113_2290 | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.795 |
hisA | AFZ20337.1 | Mic7113_3289 | Mic7113_4664 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | 0.893 |
hisA | hisB | Mic7113_3289 | Mic7113_2171 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.984 |
hisA | hisC | Mic7113_3289 | Mic7113_4125 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | Histidinol phosphate aminotransferase apoenzyme; PFAM: Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.926 |
hisA | hisD | Mic7113_3289 | Mic7113_5562 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.984 |
hisA | hisF | Mic7113_3289 | Mic7113_2956 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | Mic7113_3289 | Mic7113_3668 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.983 |
hisA | hisH | Mic7113_3289 | Mic7113_4735 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisA | hisI | Mic7113_3289 | Mic7113_3024 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisI-2 | Mic7113_3289 | Mic7113_4800 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisZ | Mic7113_3289 | Mic7113_2290 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein. | ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.920 |
hisB | AFZ20337.1 | Mic7113_2171 | Mic7113_4664 | PFAM: Imidazoleglycerol-phosphate dehydratase. | L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II. | 0.926 |