STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (651 aa)    
Predicted Functional Partners:
uvrA
UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.999
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 0.998
uvrD1
Putative DNA helicase II homolog; Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity); sp|P45612|UVRD_MYCCT;evalue=4e-011; PctID=44.94; score=70.1.
 
 
 0.919
uvrD3
DNA helicase II; Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair; sp|Q05311|UVRD_SALTY;evalue=2e-008; PctID=46.97; score=59.7.
  
 
 0.843
MCBB_0873
DNA helicase II related protein; tr|F6D1R0|F6D1R0_METPW;evalue=0.0; PctID=78.64; score=896; {ECO:0000313|EMBL:AEG17863,1}.
  
 
 0.843
MCBB_1413
Type I restriction-modification system methyltransferase subunit; tr|I3Z5V9|I3Z5V9_BELBD;evalue=2e-110; PctID=36.27; score=407; {ECO:0000313|EMBL:AFL84627,1}.
  
 
 0.843
hsdM
Type I restriction enzyme EcoEI M protein; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...]
   
 
 0.816
MCBB_1417
Putative adenine-specific methylase MJ1220; sp|Q58617|Y1220_METJA;evalue=6e-058; PctID=33.98; score=225.
   
 
 0.816
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; sp|Q2NF42|GSA_METST;evalue=1e-163; PctID=65.55; score=576; {ECO:0000255|HAMAP-Rule:MF_00375}.
     
 0.758
trxB
Thioredoxin reductase; sp|P66010|TRXB_STAAM,sp|P66011|TRXB_STAAW, sp|P99101|TRXB_STAAN,sp|Q5HHQ4|TRXB_STAAC, sp|Q6GB66|TRXB_STAAS;evalue=2e-055; PctID=42.05; score=216.
  
  
 0.620
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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