STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ahpCAlkyl hydroperoxidase; COG0450 Peroxiredoxin (186 aa)    
Predicted Functional Partners:
AFM81195.1
COG3634 Alkyl hydroperoxide reductase, large subunit
  
 0.994
AFM80928.1
COG0492 Thioredoxin reductase; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
 
 
 0.856
AFM81295.1
COG0492 Thioredoxin reductase
  
 
 0.793
tpx
Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily
  
  
 0.710
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family
  
 
 0.705
AFM81046.1
Transcriptional repressor; COG0735 Fe2+/Zn2+ uptake regulation proteins; Belongs to the Fur family
  
  
 0.686
AFM81076.1
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems
  
  
 0.686
AFM82157.1
Thioredoxin; COG0526 Thiol-disulfide isomerase and thioredoxins; Belongs to the thioredoxin family
  
 
 0.658
dps
DNA protection during starvation protein; Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral (By similarity). It binds and incorporates Fe(2+) ion. Effectively inhibits hydroxyl radical formation by the Fenton reaction and is essential for colony formation in the presence of air. Is also able to bind zinc ion. Does not bind DNA; Belongs to the Dps family
  
  
 0.604
groEL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
  
 
 0.601
Your Current Organism:
Streptococcus mutans GS5
NCBI taxonomy Id: 1198676
Other names: S. mutans GS-5, Streptococcus mutans GS-5, Streptococcus mutans GS5
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