node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NMB0473 | bioH | NMB0473 | NMB0270 | Conserved hypothetical protein; Identified by similarity to EGAD:28546; match to protein family HMM PF04301. | Putative bioH protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.900 |
NMB0473 | fabI | NMB0473 | NMB0336 | Conserved hypothetical protein; Identified by similarity to EGAD:28546; match to protein family HMM PF04301. | Enoyl-(acyl-carrier-protein) reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity). | 0.900 |
bioH | NMB0473 | NMB0270 | NMB0473 | Putative bioH protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | Conserved hypothetical protein; Identified by similarity to EGAD:28546; match to protein family HMM PF04301. | 0.900 |
bioH | fabI | NMB0270 | NMB0336 | Putative bioH protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | Enoyl-(acyl-carrier-protein) reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity). | 0.907 |
bioH | lipB-2 | NMB0270 | NMB1217 | Putative bioH protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.737 |
fabD | fabF-1 | NMB1918 | NMB0219 | Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to EGAD:22444; match to protein family HMM PF00698; match to protein family HMM TIGR00128. | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 0.999 |
fabD | fabF-2 | NMB1918 | NMB1703 | Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to EGAD:22444; match to protein family HMM PF00698; match to protein family HMM TIGR00128. | 3-oxoacyl-(acyl-carrier-protein) synthase II; Identified by similarity to EGAD:125117; match to protein family HMM PF00109; match to protein family HMM PF02801; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.994 |
fabD | fabG-1 | NMB1918 | NMB1702 | Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to EGAD:22444; match to protein family HMM PF00698; match to protein family HMM TIGR00128. | 3-oxoacyl-(acyl-carrier-protein) reductase; Identified by similarity to EGAD:97822; match to protein family HMM PF00106; match to protein family HMM TIGR01831; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.964 |
fabD | fabG-2 | NMB1918 | NMB1921 | Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to EGAD:22444; match to protein family HMM PF00698; match to protein family HMM TIGR00128. | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.991 |
fabD | fabH | NMB1918 | NMB1916 | Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to EGAD:22444; match to protein family HMM PF00698; match to protein family HMM TIGR00128. | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. | 0.999 |
fabD | fabI | NMB1918 | NMB0336 | Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to EGAD:22444; match to protein family HMM PF00698; match to protein family HMM TIGR00128. | Enoyl-(acyl-carrier-protein) reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity). | 0.989 |
fabD | fabZ | NMB1918 | NMB0179 | Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to EGAD:22444; match to protein family HMM PF00698; match to protein family HMM TIGR00128. | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.974 |
fabF-1 | fabD | NMB0219 | NMB1918 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to EGAD:22444; match to protein family HMM PF00698; match to protein family HMM TIGR00128. | 0.999 |
fabF-1 | fabF-2 | NMB0219 | NMB1703 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 3-oxoacyl-(acyl-carrier-protein) synthase II; Identified by similarity to EGAD:125117; match to protein family HMM PF00109; match to protein family HMM PF02801; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.918 |
fabF-1 | fabG-1 | NMB0219 | NMB1702 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 3-oxoacyl-(acyl-carrier-protein) reductase; Identified by similarity to EGAD:97822; match to protein family HMM PF00106; match to protein family HMM TIGR01831; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.955 |
fabF-1 | fabG-2 | NMB0219 | NMB1921 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.981 |
fabF-1 | fabH | NMB0219 | NMB1916 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. | 0.991 |
fabF-1 | fabI | NMB0219 | NMB0336 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | Enoyl-(acyl-carrier-protein) reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity). | 0.982 |
fabF-1 | fabZ | NMB0219 | NMB0179 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.957 |
fabF-1 | lipB-2 | NMB0219 | NMB1217 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.806 |