node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhs | gcvH | NMB1839 | NMB0575 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.437 |
fhs | gcvT | NMB1839 | NMB0574 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.945 |
fhs | glyA | NMB1839 | NMB1055 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.962 |
fhs | lpdA2 | NMB1839 | NMB1344 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by similarity to GP:1006678; match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.461 |
fhs | metF | NMB1839 | NMB0943 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate reductase; Identified by similarity to EGAD:28443; match to protein family HMM PF02219; match to protein family HMM TIGR00676. | 0.580 |
fhs | purH | NMB1839 | NMB0983 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to EGAD:9161; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.984 |
fhs | purL | NMB1839 | NMB1996 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.972 |
fhs | purN | NMB1839 | NMB1566 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.960 |
gcvH | fhs | NMB0575 | NMB1839 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.437 |
gcvH | gcvT | NMB0575 | NMB0574 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | glyA | NMB0575 | NMB1055 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.962 |
gcvH | lpdA2 | NMB0575 | NMB1344 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by similarity to GP:1006678; match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.994 |
gcvH | metF | NMB0575 | NMB0943 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 5,10-methylenetetrahydrofolate reductase; Identified by similarity to EGAD:28443; match to protein family HMM PF02219; match to protein family HMM TIGR00676. | 0.737 |
gcvT | fhs | NMB0574 | NMB1839 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:7856; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.945 |
gcvT | gcvH | NMB0574 | NMB0575 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcvT | glyA | NMB0574 | NMB1055 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
gcvT | lpdA2 | NMB0574 | NMB1344 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by similarity to GP:1006678; match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.995 |
gcvT | metF | NMB0574 | NMB0943 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 5,10-methylenetetrahydrofolate reductase; Identified by similarity to EGAD:28443; match to protein family HMM PF02219; match to protein family HMM TIGR00676. | 0.948 |
gcvT | purH | NMB0574 | NMB0983 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to EGAD:9161; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.939 |
gcvT | purN | NMB0574 | NMB1566 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.932 |