STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysG-2Siroheme synthase; Identified by similarity to EGAD:142433; match to protein family HMM PF00590; match to protein family HMM TIGR01469; match to protein family HMM TIGR01470. (483 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.976
cysH-2
Phosphoadenosine phosphosulfate reductase; Identified by similarity to EGAD:151586; match to protein family HMM PF01507; match to protein family HMM TIGR02055.
 
  
 0.972
cysI-2
Sulfite reductase hemoprotein, beta-component; Identified by similarity to EGAD:21188; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM TIGR02041.
 
  
 0.953
cysD-2
Sulfate adenylyltransferase, subunit 2; Identified by similarity to EGAD:46109; match to protein family HMM PF01507; match to protein family HMM TIGR02039.
  
  
 0.945
cysI-1
Sulfite reductase hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.910
cysH-1
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.886
cysG-1
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
  
0.882
cysJ-2
Sulfite reductase (NADPH) flavoprotein, alpha component; Identified by similarity to EGAD:22695; match to protein family HMM PF00175; match to protein family HMM PF00258; match to protein family HMM PF00667; match to protein family HMM TIGR01931.
  
  
 0.865
cysD-1
Sulfate adenylyltransferase, subunit 2; Identified by similarity to EGAD:46109; match to protein family HMM PF01507; match to protein family HMM TIGR02039.
  
  
 0.851
hemB
Delta-aminolevulinic acid dehydratase; Identified by similarity to EGAD:38458; match to protein family HMM PF00490; Belongs to the ALAD family.
 
  
 0.841
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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