node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroC | hisC | NMB1680 | NMB1582 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol-phosphate aminotransferase; Identified by similarity to EGAD:156515; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.775 |
aroC | hisD | NMB1680 | NMB1581 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.823 |
hisA | hisB | NMB0629 | NMB1583 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | 0.993 |
hisA | hisC | NMB0629 | NMB1582 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidinol-phosphate aminotransferase; Identified by similarity to EGAD:156515; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.965 |
hisA | hisD | NMB0629 | NMB1581 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
hisA | hisE | NMB0629 | NMB0603 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | phosphoribosyl-ATP pyrophosphatase; Identified by similarity to EGAD:35950; match to protein family HMM PF01503. | 0.979 |
hisA | hisF | NMB0629 | NMB0628 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisA | hisG | NMB0629 | NMB1579 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.993 |
hisA | hisH | NMB0629 | NMB0630 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | NMB0629 | NMB0627 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisS-1 | NMB0629 | NMB0814 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.909 |
hisB | hisA | NMB1583 | NMB0629 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to EGAD:33359; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.993 |
hisB | hisC | NMB1583 | NMB1582 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | Histidinol-phosphate aminotransferase; Identified by similarity to EGAD:156515; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | NMB1583 | NMB1581 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | NMB1583 | NMB0603 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | phosphoribosyl-ATP pyrophosphatase; Identified by similarity to EGAD:35950; match to protein family HMM PF01503. | 0.978 |
hisB | hisF | NMB1583 | NMB0628 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.998 |
hisB | hisG | NMB1583 | NMB1579 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.991 |
hisB | hisH | NMB1583 | NMB0630 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.998 |
hisB | hisI | NMB1583 | NMB0627 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.988 |
hisB | hisS-1 | NMB1583 | NMB0814 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:9090; match to protein family HMM PF00475. | histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.932 |