node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACO03731.1 | argD | PERMA_1230 | PERMA_0177 | 8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155. | Acetylornithine aminotransferase (acoat); Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | 0.433 |
ACO03731.1 | bioA | PERMA_1230 | PERMA_0901 | 8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155. | Adenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.997 |
ACO03731.1 | bioB | PERMA_1230 | PERMA_1355 | 8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.951 |
ACO03731.1 | bioD | PERMA_1230 | PERMA_0649 | 8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.977 |
ACO03731.1 | bioW | PERMA_1230 | PERMA_1854 | 8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155. | 6-carboxyhexanoate--CoA ligase; Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP. | 0.996 |
ACO03731.1 | birA | PERMA_1230 | PERMA_1238 | 8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155. | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.523 |
ACO04244.1 | bioB | PERMA_1357 | PERMA_1355 | VI polysaccharide biosynthesis protein VipB/tviC; Identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.634 |
ACO04244.1 | lpxB | PERMA_1357 | PERMA_1354 | VI polysaccharide biosynthesis protein VipB/tviC; Identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.460 |
ACO04420.1 | bioB | PERMA_1353 | PERMA_1355 | Putative membrane protein; Identified by match to protein family HMM PF03649; match to protein family HMM TIGR00245. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.474 |
ACO04420.1 | lpxB | PERMA_1353 | PERMA_1354 | Putative membrane protein; Identified by match to protein family HMM PF03649; match to protein family HMM TIGR00245. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.610 |
argD | ACO03731.1 | PERMA_0177 | PERMA_1230 | Acetylornithine aminotransferase (acoat); Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | 8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155. | 0.433 |
argD | bioB | PERMA_0177 | PERMA_1355 | Acetylornithine aminotransferase (acoat); Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.760 |
argD | hisI | PERMA_0177 | PERMA_0366 | Acetylornithine aminotransferase (acoat); Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | Histidine biosynthesis bifunctional protein hisIE; Identified by match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; In the N-terminal section; belongs to the PRA-CH family. | 0.501 |
bioA | ACO03731.1 | PERMA_0901 | PERMA_1230 | Adenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155. | 0.997 |
bioA | bioB | PERMA_0901 | PERMA_1355 | Adenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.996 |
bioA | bioD | PERMA_0901 | PERMA_0649 | Adenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
bioA | bioW | PERMA_0901 | PERMA_1854 | Adenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 6-carboxyhexanoate--CoA ligase; Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP. | 0.753 |
bioA | birA | PERMA_0901 | PERMA_1238 | Adenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.512 |
bioB | ACO03731.1 | PERMA_1355 | PERMA_1230 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155. | 0.951 |
bioB | ACO04244.1 | PERMA_1355 | PERMA_1357 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | VI polysaccharide biosynthesis protein VipB/tviC; Identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993. | 0.634 |