STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C725_11185,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (315 aa)    
Predicted Functional Partners:
C725_1120
5-methyltetrahydrofolate--homocysteine methyltransferase.
 
 
 0.998
C725_1119
Putative methyltransferase.
 
 
 0.996
C725_0620
Aminomethyltransferase; Glycine cleavage system T protein.
  
 
 0.961
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.934
folD
Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.925
C725_1828
S-adenosylmethionine synthetase.
  
 
 0.916
C725_0790
Thymidylate synthase.
     
 0.912
C725_1117
Transcriptional regulator, ArsR family / Methyltransferase fusion.
 
   
 0.905
C725_1719
Cystathionine beta-lyase.
  
 0.857
C725_1318
Cystathionine gamma-synthase.
  
 0.792
Your Current Organism:
Pacificimonas flava
NCBI taxonomy Id: 1234595
Other names: CGMCC 1.12401, LMG 27364, LMG:27364, P. flava, Pacificamonas flava, Pacificimonas flava corrig. Liu et al. 2016, alpha proteobacterium JLT2015, strain JLT2015
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