STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACA1_192970Basic helixloop-helix (BHLH) family protein. (186 aa)    
Predicted Functional Partners:
ACA1_256390
Histidinol dehydrogenase; Belongs to the HisA/HisF family.
  
 
 0.963
ACA1_374140
BRCA1 C Terminus (BRCT) domain containing protein.
   
 0.940
ACA1_258010
BRCA1 C Terminus (BRCT) domain containing protein.
   
 0.940
ACA1_244870
DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
   
 0.827
ACA1_258230
DNA ligase.
  
 0.735
ACA1_280590
Poly(ADPribose) polymerase and DNA-Ligase Zn-finger region domain containing protein.
  
 0.735
ACA1_296520
CUE domain containing protein.
  
 0.735
ACA1_184770
Histidinolphosphate transaminase.
  
 
 0.724
ACA1_183710
ATPdependent DNA ligase domain containing protein.
  
 0.705
ACA1_138050
Tyrosyl-DNA phosphodiesterase.
    
 
 0.689
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.