STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACA1_064250AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (1055 aa)    
Predicted Functional Partners:
ACA1_380800
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
   
 0.996
ACA1_287560
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
   
 0.996
ACA1_096470
Dual specificity phosphatase, catalytic domain containing protein.
   
 0.991
ACA1_160880
Clathrin adaptor complex small chain subfamily protein.
   
 0.982
ACA1_160760
Clathrin coat assembly protein AP50, putative.
   
 0.974
ACA1_358660
SH3 domain containing protein.
    
 0.964
ACA1_107430
RhoGEF domain containing protein.
    
 0.964
ACA1_112020
RhoGEF domain containing protein.
    
 0.964
ACA1_175570
RhoGEF domain containing protein.
    
 0.964
ACA1_217370
Adaptorrelated protein complex 1, beta 1 subunit, isoform 2, putative.
   
0.962
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
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