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glnD protein (Dermacoccus nishinomiyaensis) - STRING interaction network
"glnD" - Bifunctional uridylyltransferase/uridylyl-removing enzyme in Dermacoccus nishinomiyaensis
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glnDBifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism (867 aa)    
Predicted Functional Partners:
HX89_09740
Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method- Protein Homology (112 aa)
 
  0.991
HX89_09745
Ammonium transporter; Derived by automated computational analysis using gene prediction method- Protein Homology (473 aa)
 
   
  0.863
HX89_08750
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] (996 aa)
 
   
  0.724
HX89_06000
Glutamine synthetase; Derived by automated computational analysis using gene prediction method- Protein Homology (474 aa)
   
   
  0.634
HX89_08145
Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology (1511 aa)
         
  0.628
HX89_08755
Glutamine synthetase; Derived by automated computational analysis using gene prediction method- Protein Homology (444 aa)
   
   
  0.612
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY; Belongs to the GTP-binding SRP family. SRP54 subfamily (538 aa)
              0.587
HX89_03270
Nitrite reductase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family (876 aa)
           
  0.581
gltD
Glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method- Protein Homology (485 aa)
           
  0.554
HX89_01640
Urease subunit gamma; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the urease gamma subunit family (100 aa)
           
  0.547
Your Current Organism:
Dermacoccus nishinomiyaensis
NCBI taxonomy Id: 1274
Other names: ATCC 29093, CCM 2140, CCUG 33028, CIP 81.71, D. nishinomiyaensis, DSM 20448, Dermacoccus nishinomiyaensis, Dermacoccus nishinomiyensis, Dermatococcus nishinomiyaensis, Dermatococcus nishinomiyensis, IEGM 393, IFO 15356, JCM 11613, LMG 14222, Micrococcus nishinomiyaensis, Micrococcus nishinomyaensis, NBRC 15356, NCTC 11039
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