STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
splBSerine protease SplB; Serine protease that cleaves specifically after the sequence Trp-Glu-Leu-Gln; Belongs to the peptidase S1B family (240 aa)    
Predicted Functional Partners:
aur
annotation not available
 
   
 0.782
lukDv
Leucotoxin LukDv; Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv- LukDv to rabbit leukocytes is similar to that of the Panton- Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin
      
 0.773
lukEv
Leucotoxin LukEv; Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv- LukDv to rabbit leukocytes is similar to that of the Panton- Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin
   
  
 0.747
splC
annotation not available
 
  
0.735
sak
annotation not available
      
 0.734
sspB
Staphopain B; Cysteine protease able to degrade elastin, fibrogen, fibronectin and kininogen. Exhibits a strong preference for substrates where arginine is preceded by a hydrophobic amino acid. Promotes detachment of primary human keratinocytes. Along with other extracellular proteases is involved in colonization and infection of human tissues
      
 0.732
sasG
Surface protein G; Promotes adhesion of bacterial cells to human squamous nasal epithelial cells, a phenomenon which is likely to be important in nasal colonization. Forms short, extremely dense and thin fibrils all over the bacterial surface. Does not bind to either buccal cells or non-differentiated keratinocytes. Promotes cellular aggregation leading to biofilm formation
      
 0.731
sdrC
Serine-aspartate repeat-containing protein C; Cell surface-associated protein which possibly mediates interactions of S.aureus with components of the extracellular matrix of higher eukaryotes. May bind calcium (By similarity)
  
   
 0.681
splA
annotation not available
 
  
0.667
ebpS
Elastin-binding protein EbpS; Promotes binding of soluble elastin peptides and tropoelastin to S.aureus cells although it is not able to promote bacterial adherence to immobilized elastin and, therefore, is not a microbial surface component recognizing adhesive matrix molecule (MSCRAMM). May be involved in sensing the environment or in nutrient transport, since its loss caused a growth defect
  
   
 0.605
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 1280
Other names: ATCC 12600, ATCC 12600-U, CCM 885, CIP 65.8, DSM 20231, HAMBI 66, JCM 20624, Micrococcus aureus, Micrococcus pyogenes, NBRC 100910, NCAIM B.01065, NCCB 72047, NCTC 8532, S. aureus, Staphlococcus pyogenes citreus, Staphylococcus aureus, Staphylococcus pyogenes aureus, Streptococcus aureus
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