STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
splAannotation not available (235 aa)    
Predicted Functional Partners:
aur
annotation not available
     
 0.816
lukDv
Leucotoxin LukDv; Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv- LukDv to rabbit leukocytes is similar to that of the Panton- Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin
      
 0.808
sspB
Staphopain B; Cysteine protease able to degrade elastin, fibrogen, fibronectin and kininogen. Exhibits a strong preference for substrates where arginine is preceded by a hydrophobic amino acid. Promotes detachment of primary human keratinocytes. Along with other extracellular proteases is involved in colonization and infection of human tissues
   
  
 0.753
hly
Alpha-hemolysin; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity (By similarity)
   
  
 0.743
sak
annotation not available
      
 0.739
lukEv
Leucotoxin LukEv; Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv- LukDv to rabbit leukocytes is similar to that of the Panton- Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin
      
 0.732
sspP
Staphopain A; Cysteine protease able to degrade elastin; Belongs to the peptidase C47 family
      
 0.731
hlgA
annotation not available
      
 0.731
sasG
Surface protein G; Promotes adhesion of bacterial cells to human squamous nasal epithelial cells, a phenomenon which is likely to be important in nasal colonization. Forms short, extremely dense and thin fibrils all over the bacterial surface. Does not bind to either buccal cells or non-differentiated keratinocytes. Promotes cellular aggregation leading to biofilm formation
      
 0.730
splB
Serine protease SplB; Serine protease that cleaves specifically after the sequence Trp-Glu-Leu-Gln; Belongs to the peptidase S1B family
 
  
0.667
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 1280
Other names: ATCC 12600, ATCC 12600-U, CCM 885, CIP 65.8, DSM 20231, HAMBI 66, JCM 20624, Micrococcus aureus, Micrococcus pyogenes, NBRC 100910, NCAIM B.01065, NCCB 72047, NCTC 8532, S. aureus, Staphlococcus pyogenes citreus, Staphylococcus aureus, Staphylococcus pyogenes aureus, Streptococcus aureus
Server load: low (10%) [HD]