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icaC protein (Staphylococcus aureus) - STRING interaction network
"icaC" - Probable poly-beta-1,6-N-acetyl-D-glucosamine export protein in Staphylococcus aureus
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Predicted Interactions
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textmining
co-expression
protein homology
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icaCProbable poly-beta-1,6-N-acetyl-D-glucosamine export protein; Presumably involved in the export of the biofilm adhesin polysaccharide poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA) across the cell membrane (294 aa)    
Predicted Functional Partners:
icaB
Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase; Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl- D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions (By similarity) (274 aa)
 
   
  0.995
icaA
Poly-beta-1,6-N-acetyl-D-glucosamine synthase; N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D- glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Requires IcaD for full activity (By similarity) (399 aa)
 
   
  0.985
icaR
Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR; Represses transcription of the icaADBC operon necessary for biofilm production (186 aa)
 
     
  0.925
clfA
Clumping factor A; Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen [...] (921 aa)
   
     
  0.849
AID41366.1
annotation not available (605 aa)
           
  0.809
clfB
Clumping factor B; Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps. Partly responsible for mediating bacterial attachment to the highly keratinized squamous epithelial cells from the nasal cavity via an interaction with cytokeratin K10 (K10). Also promotes bacterial attachment to cultured keratinocytes, possibly through an interaction with cytokeratin K10. Binds mouse cytokeratin K10. Activates human platelet aggregation; Belongs to the serine-aspa [...] (903 aa)
   
     
  0.805
ebpS
Elastin-binding protein EbpS; Promotes binding of soluble elastin peptides and tropoelastin to S.aureus cells although it is not able to promote bacterial adherence to immobilized elastin and, therefore, is not a microbial surface component recognizing adhesive matrix molecule (MSCRAMM). May be involved in sensing the environment or in nutrient transport, since its loss caused a growth defect (486 aa)
   
     
  0.782
fnbA
Fibronectin-binding protein A; Possesses multiple, substituting fibronectin (Fn) binding regions, each capable of conferring adherence to both soluble and immobilized forms of Fn. This confers to S.aureus the ability to invade endothelial cells both in vivo and in vitro, without requiring additional factors, although in a slow and inefficient way through actin rearrangements in host cells. This invasion process is mediated by integrin alpha-5/beta-1. Promotes bacterial attachment to both soluble and immobilized forms of fibrinogen (Fg) by means of a unique binding site localized within [...] (995 aa)
           
  0.737
fib
annotation not available (165 aa)
           
  0.734
AID39216.1
annotation not available (157 aa)
   
          0.718
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 1280
Other names: ATCC 12600, ATCC 12600-U, CCM 885, CIP 65.8, DSM 20231, HAMBI 66, JCM 20624, Micrococcus aureus, Micrococcus pyogenes, NBRC 100910, NCAIM B.01065, NCCB 72047, NCTC 8532, S. aureus, Staphlococcus pyogenes citreus, Staphylococcus aureus, Staphylococcus pyogenes aureus, Streptococcus aureus
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