STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPHB5Glycoprotein hormone beta-5. (130 aa)    
Predicted Functional Partners:
CGA
Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.
     
 0.689
LGR6
Leucine-rich repeat-containing G-protein coupled receptor 6.
     
 0.562
LHCGR
Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
     
 0.562
FSHR
Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
     
 0.562
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
     
 0.562
POP4
Ribonuclease P protein subunit p29.
      
 0.471
TMEM254
Transmembrane protein 254.
      
 0.459
LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4.
     
 0.434
RXFP1
Relaxin receptor 1.
     
 0.434
LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5.
     
 0.434
Your Current Organism:
Nipponia nippon
NCBI taxonomy Id: 128390
Other names: Ibis nippon, N. nippon, crested ibis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.