STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)    
Predicted Functional Partners:
GNA11
Guanine nucleotide-binding protein subunit alpha-11.
    
 0.959
GNA14
Guanine nucleotide-binding protein subunit alpha-14.
    
 0.959
PLCB1
Phosphoinositide phospholipase C.
  
  
0.947
PLCB2
Phosphoinositide phospholipase C.
     
0.946
GNAI2
Guanine nucleotide-binding protein G(I) subunit alpha-2.
   
 0.932
GNAI3
Guanine nucleotide-binding protein G(K) subunit alpha.
   
 0.932
CASR
Extracellular calcium-sensing receptor.
     
 0.925
ITPKA
Kinase; Belongs to the inositol phosphokinase (IPK) family.
     
 0.917
PRKCA
Protein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
     
 0.912
PRKCB
Protein kinase C beta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
     
 0.912
Your Current Organism:
Nipponia nippon
NCBI taxonomy Id: 128390
Other names: Ibis nippon, N. nippon, crested ibis
Server load: medium (44%) [HD]