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hrcA protein (Staphylococcus xylosus) - STRING interaction network
"hrcA" - Heat-inducible transcription repressor HrcA in Staphylococcus xylosus
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second shell of interactors
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Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (326 aa)    
Predicted Functional Partners:
mcsB
Protein-arginine kinase; Catalyzes the specific phosphorylation of arginine residues in proteins (336 aa)
     
   
  0.999
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent [...] (203 aa)
   
   
  0.997
dnaK
Chaperone protein DnaK; Acts as a chaperone (614 aa)
   
   
  0.997
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (378 aa)
   
   
  0.919
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (95 aa)
     
   
  0.848
lepA
Elongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (607 aa)
         
  0.789
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (540 aa)
   
   
  0.732
AID42641.1
Oxygen-independent coproporphyrinogen-III oxidase-like protein; Involved in the biosynthesis of porphyrin-containing compound (374 aa)
         
  0.730
AID42647.1
Ribosomal RNA small subunit methyltransferase E; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (250 aa)
   
   
  0.695
prmA
Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11 (312 aa)
   
   
  0.691
Your Current Organism:
Staphylococcus xylosus
NCBI taxonomy Id: 1288
Other names: ATCC 29971, CCUG 7324, CIP 81.66, DSM 20266, HAMBI 2057, JCM 2418, NCTC 11043, NRRL B-14776, S. xylosus, Staphylococcus xylosus
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