STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gasu_46310DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (711 aa)    
Predicted Functional Partners:
Gasu_10570
DNA gyrase subunit A.
 
     0.841
Gasu_03410
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.
  
  
 0.760
Gasu_14290
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.699
Gasu_17860
Structural maintenance of chromosome (SMC ATPase family) isoform 1.
   
 
 0.667
Gasu_35620
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 
 0.605
Gasu_15610
Structural maintenance of chromosomes protein.
   
 
 0.592
Gasu_22180
Condensin complex subunit 2.
   
 
 0.542
Gasu_61800
Ubiquitin-conjugating enzyme 29; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.524
Gasu_35530
Ubiquitin-conjugating enzyme E2; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.524
Gasu_21610
DNA repair protein SMC6.
   
 
 0.515
Your Current Organism:
Galdieria sulphuraria
NCBI taxonomy Id: 130081
Other names: G. sulphuraria, SAG 17.91
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.