STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (345 aa)    
Predicted Functional Partners:
ilvN
Protein synonym:acetohydroxy-acid synthase small subunit.
 
 
 0.999
ilvB
Protein synonym:acetohydroxy-acid synthase large subunit.
 
 
 0.998
ilvD
Dihydroxy-acid dehydratase.
 
 
 0.998
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 0.986
leuB
3-isopropylmalate dehydrogenase.
 
  
 0.964
leuD
3-isopropylmalate dehydratase small subunit.
 
  
 0.960
leuA
Protein synonym:alpha-isopropylmalate synthase.
  
  
 0.895
gltB
Glutamate synthase large subunit; Protein synonym:glutamine 2-oxoglutarate aminotransferase large subunit.
  
  
 0.812
leuA-2
Putative 2-isopropylmalate synthase; Protein synonym:alpha-isopropylmalate synthase.
  
  
 0.791
ilvE
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.772
Your Current Organism:
Ilumatobacter coccineus
NCBI taxonomy Id: 1313172
Other names: Acidimicrobidae bacterium YM16-304, I. coccineus YM16-304, Ilumatobacter coccineum YM16-304, Ilumatobacter coccineus YM16-304
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