STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sloAlveolysin; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)    
Predicted Functional Partners:
nga
N-acetylglucosamine-1-phosphate uridyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.978
ifs
NAD glycohydrolase inhibitor; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.883
hasA
Hyaluronan synthase; Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant; Belongs to the NodC/HAS family.
  
  
 0.873
SpeG
Exosortase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.864
ska
Kinase; This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells (By similarity).
      
 0.863
speB
Peptidase C10; Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Belongs to the peptidase C10 family.
      
 0.863
csrS
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.840
RocA
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.830
SmeZ
Exosortase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.826
csrR
PhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.826
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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