STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
addAATP-dependent helicase/nuclease subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology. (1210 aa)    
Predicted Functional Partners:
rexB
ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.999
recJ
Single-stranded DNA exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.789
polA
DNA polymerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.706
recO
DNA recombination protein RecO; Involved in DNA repair and RecF pathway recombination.
  
  
 0.695
AKZ50224.1
SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.689
recX
Recombination regulator RecX; Binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.681
recF
Recombinase RecF; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.680
recA
Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.675
ligA
NAD-dependent DNA ligase LigA; This protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.669
recG
ATP-dependent DNA helicase RecG; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.655
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.