STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mlhBEsterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)    
Predicted Functional Partners:
dltC
Alanine-phosphoribitol ligase; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
   
 
 0.836
AKZ50298.1
Deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.756
dltA
Alanine-phosphoribitol ligase; Transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.738
dltD
Cytochrome C552; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.720
dltB
D-alanyl-lipoteichoic acid biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.648
AKZ50536.1
D-alanyl-lipoteichoic acid biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.634
engA
GTP-binding protein Der; EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.629
AKZ50649.1
Deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.623
AKZ50977.1
Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.526
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
   
 
 0.513
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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