STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fhs2Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)    
Predicted Functional Partners:
FolD
5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.992
glyA
Serine hydroxymethyltransferase; Catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.980
ftcD
Glutamate formiminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.973
AKZ49606.1
IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.964
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.949
dhfR
Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family.
  
 
 0.920
HutU
Urocanate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.913
hutH
Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.904
Fhs1
Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.902
AKZ49602.1
Phosphoribosylformylglycinamidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.808
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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