STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_1429Putative HMP/thiamine permease protein ykoE; Predicted membrane protein. (194 aa)    
Predicted Functional Partners:
ACPL_1427
Putative permease ybaF; ABC-type cobalt transport system, permease component CbiQ and related transporters.
 
  
 0.988
ACPL_1428
Ribose import ATP-binding protein rbsA; ATPase components of various ABC-type transport systems, contain duplicated ATPase.
 
  
 0.983
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
   
  
 0.571
ACPL_2440
Uncharacterized protein; ABC-type cobalt transport system, permease component CbiQ and related transporters.
  
  
 0.537
thiD
Hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase.
  
    0.526
thiG
Thiamine biosynthesis ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
    0.519
ACPL_819
Ycf40-like uncharacterized protein.
  
    0.504
pnuC-2
Nicotinamide mononucleotide transporter.
 
   
 0.459
ACPL_1426
Hypothetical protein.
       0.458
ACPL_1909
ydbT-like uncharacterized transmembrane protein; Predicted membrane protein.
  
     0.448
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.