Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Putative DNA helicase INO80; DNA helicase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair; Belongs to the SNF2/RAD54 helicase family (1673 aa)
Predicted Functional Partners:
Uncharacterized protein; Belongs to the actin family (747 aa)
RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes (484 aa)
RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes (461 aa)
Uncharacterized protein; Belongs to the actin family (480 aa)
Uncharacterized protein (189 aa)
Uncharacterized protein (1084 aa)
Uncharacterized protein (731 aa)
Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex (733 aa)