Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Nitroreductase family protein; antibiot_sagB- SagB-type dehydrogenase domain protein (513 aa)
Predicted Functional Partners:
Uncharacterized protein (639 aa)
YcaO-like family protein; Cyclo_dehyd_2- bacteriocin biosynthesis cyclodehydratase domain (649 aa)
annotation not available (196 aa)
Rbstp2229 protein (130 aa)
Uncharacterized protein (91 aa)
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (418 aa)