Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
TVP38/TMEM64 family inner membrane protein YdjZ (197 aa)
Predicted Functional Partners:
sigpep_I_bact- signal peptidase I; Belongs to the peptidase S26 family (187 aa)
ATP-dependent helicase/deoxyribonuclease subunit B; ATP-dependent DNA helicase; Belongs to the helicase family. AddB/RexB type 1 subfamily (1171 aa)
ATP-dependent helicase/nuclease subunit A; ATP-dependent DNA helicase (1241 aa)
annotation not available (193 aa)
annotation not available (152 aa)
Bacterial RNA polymerase, alpha chain C terminal domain protein (95 aa)
annotation not available (114 aa)
Multifunctional fusion protein; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (321 aa)